PH reduction

Across TCGA patient cohorts, RNA activity of the PH reduction pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR2467, CXCL6, and SLC35E1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, PH reduction activity versus MIR2467 in GBM (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MIR2467 →	-0.493	-0.505	.007	.001	3	4
COAD	CXCL6 →	+1.065	+0.097	.002	.009	3	4
BRCA	SLC35E1 →	-0.428	-0.105	.002	.008	3	3
BRCA	LONP1 →	-0.895	-0.163	.001	.001	3	3
GBM	GPR143 →	+0.441	+0.698	<.001	<.001	3	3
GBM	HHATL →	+1.573	+0.820	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045851 vs MIR2467 — GBM

Explore this scatter interactively →