PH reduction

Across TCGA cell cohorts, RNA activity of the PH reduction pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTN, FARP2, and AADAT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTN grouped by PH reduction-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PTN →	+0.096	+0.958	.003	<.001	3	4
BLOOD_Myeloma	FARP2 →	-0.297	-0.149	.003	.003	3	3
BLOOD_Myeloma	AADAT →	-0.286	-0.122	.008	.001	3	3
BLOOD_Myeloma	H2BC11 →	-0.147	-0.151	.002	<.001	3	3
BLOOD_Myeloma	ADAM30 →	+0.255	+0.159	.006	.002	2	4
BLOOD_Myeloma	UTS2R →	-0.197	-0.106	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTN by PH reduction activity — OESOPHAGUS

Explore this box plot interactively →