Positive regulation of mitotic nuclear division

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic nuclear division pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMT2, CHURC1-FNTB, and KDM6B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NMT2 grouped by Positive regulation of mitotic nuclear division-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NMT2 →	+0.383	+0.259	.002	.005	3	3
LUNG_NSCLC_LUAD	CHURC1-FNTB →	-0.236	-0.940	<.001	.002	3	3
LIVER	KDM6B →	-0.269	-0.405	.006	.008	3	3
BLOOD_Myeloma	LCN2 →	+0.220	+0.485	.008	<.001	3	3
OVARY	IL27 →	+0.265	+0.259	.002	.008	3	3
LUNG_SCLC	BRD9 →	+0.189	+1.030	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NMT2 by Positive regulation of mitotic nuclear division activity — BLOOD_Lymphoma

Explore this box plot interactively →