Negative regulation of membrane potential

Across TCGA patient cohorts, RNA activity of the Negative regulation of membrane potential pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERP44, CORO2A, and ETF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of membrane potential activity versus ERP44 in CCRCC (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ERP44 →	-0.228	-0.042	<.001	<.001	3	6
LSCC	CORO2A →	-0.305	-0.054	<.001	<.001	3	5
CCRCC	ETF1 →	-0.211	-0.043	<.001	<.001	3	5
CCRCC	ITPR3 →	-0.421	-0.046	<.001	.001	3	5
PDAC	SLC12A9 →	-0.239	-0.048	.009	.003	2	5
GBM	BASP1 →	+0.565	+0.058	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045837 vs ERP44 — CCRCC

Explore this scatter interactively →