Negative regulation of membrane potential

Across TCGA patient cohorts, RNA activity of the Negative regulation of membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4A, RPL12P41, and CYSLTR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of membrane potential activity versus C4A in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C4A →	+1.786	+0.626	<.001	.001	3	4
BRCA	RPL12P41 →	-1.186	-0.569	<.001	.007	3	3
CCRCC	CYSLTR1 →	-0.320	-0.294	.007	.005	3	3
LSCC	CARD8 →	+0.324	+0.615	<.001	.001	3	3
LSCC	SP140 →	+0.528	+0.457	<.001	.003	3	3
GBM	GPN1 →	-0.281	-0.123	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045837 vs C4A — BRCA

Explore this scatter interactively →