Positive regulation of meiotic nuclear division

Across TCGA patient cohorts, RNA activity of the Positive regulation of meiotic nuclear division pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSX2_S91, FERMT1, and KIF3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of meiotic nuclear division activity versus MSX2_S91 in UCEC (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSX2_S91 →	+0.964	+0.083	<.001	<.001	3	5
UCEC	FERMT1 →	+0.548	+0.068	.001	<.001	3	5
HNSC	KIF3A →	+0.198	+0.051	.001	.006	3	4
UCEC	RCN2 →	+0.578	+0.094	<.001	<.001	3	4
UCEC	TNFAIP2_S68 →	-0.499	-0.052	.006	.008	3	4
UCEC	CLASP1_S559 →	-0.361	-0.060	.006	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045836 vs MSX2_S91 — UCEC

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