Positive regulation of meiotic nuclear division

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of meiotic nuclear division pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BLCA, show the opposite pattern, with lower activity in tumor tissue.

KIRC, COAD, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	All	IV	+0.077	<.001	12	view →
COAD	Female	All	+0.102	<.001	10	view →
HNSC	Male	IV	+0.068	<.001	10	view →
KIRP	Male	II,III,IV	+0.084	<.001	9	view →
KICH	All	II,III,IV	+0.050	<.001	9	view →
LIHC	Male	All	+0.074	<.001	7	view →
LUSC	All	All	+0.034	<.001	5	view →
UCEC	All	All	+0.049	.010	4	view →
BLCA	All	All	−0.041	.017	4	view →
STAD	All	All	+0.034	.003	4	view →
READ	All	All	+0.059	.005	3	view →
CHOL	Male	All	+0.091	.002	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0045836–KIRC

Open the KIRC breakdown →