Positive regulation of meiotic nuclear division

Across TCGA cell cohorts, RNA activity of the Positive regulation of meiotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL25, PDE7A, and PECAM1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of meiotic nuclear division activity versus METTL25 in BLOOD_Leukemia (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	METTL25 →	+0.950	+0.383	.004	.006	3	2
BLOOD_Leukemia	PDE7A →	+1.734	+0.339	.007	.006	3	2
BLOOD_Leukemia	PECAM1 →	+5.439	+0.358	<.001	.003	3	2
BLOOD_Leukemia	MFSD11 →	+0.745	+0.388	.002	.003	2	2
BLOOD_Leukemia	COL17A1 →	+0.269	+0.481	.002	.001	2	2
BLOOD_Leukemia	NUP133 →	+0.493	+0.273	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045836 vs METTL25 — BLOOD_Leukemia

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