Positive regulation of lipid metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QTNF7, DACT3, and PLN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid metabolic process activity versus C1QTNF7 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C1QTNF7 →	+0.795	+1.100	<.001	<.001	3	7
PDAC	DACT3 →	+0.400	+0.237	.001	.001	3	6
LSCC	PLN →	+1.117	+0.843	<.001	<.001	3	6
LSCC	ISM1 →	+0.867	+0.858	<.001	<.001	3	6
LSCC	CNN1 →	+0.798	+0.767	<.001	<.001	3	6
HNSC	JPH2 →	+0.806	+0.558	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045834 vs C1QTNF7 — LSCC

Explore this scatter interactively →