Positive regulation of lipid metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR34, KLK1, and MYNN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR34 grouped by Positive regulation of lipid metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GPR34 →	+0.330	+0.070	.004	.007	3	6
BREAST	KLK1 →	-0.267	-0.083	.002	<.001	3	5
LARGE_INTESTINE	MYNN →	+0.130	+0.042	.002	<.001	3	5
LUNG_SCLC	METTL2A →	+0.310	+0.083	<.001	.003	3	4
LUNG_SCLC	OPA1 →	+0.412	+0.068	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ABHD14B →	+0.346	+0.093	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR34 by Positive regulation of lipid metabolic process activity — KIDNEY

Explore this box plot interactively →