Negative regulation of lipid metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipid metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC91, TAF4, and SLCO1B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC91 grouped by Negative regulation of lipid metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCDC91 →	-0.205	-0.071	.008	.004	3	5
LARGE_INTESTINE	TAF4 →	+0.325	+0.109	.002	.002	3	4
BONE	SLCO1B1 →	-0.188	-0.072	.001	.003	3	4
BONE	ZNF431 →	-0.285	-0.116	<.001	.004	3	4
BREAST	ZBTB2 →	+0.107	+0.066	.004	<.001	2	5
LARGE_INTESTINE	BBC3 →	-0.233	-0.077	.004	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC91 by Negative regulation of lipid metabolic process activity — CNS

Explore this box plot interactively →