Negative regulation of lipid metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYK, MFSD10, and IMPA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid metabolic process activity versus SYK in BLOOD_Lymphoma (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SYK →	-3.705	-0.932	.006	.006	2	6
LIVER	MFSD10 →	+0.710	+0.269	.005	.004	3	4
LIVER	IMPA1 →	+0.677	+0.285	<.001	<.001	3	4
LIVER	VPS28 →	+0.659	+0.280	<.001	<.001	3	4
CNS	ARMC9 →	+1.203	+0.186	.004	.002	3	4
STOMACH	EZR →	-1.277	-0.277	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045833 vs SYK — BLOOD_Lymphoma

Explore this scatter interactively →