Positive regulation of isotype switching

Across TCGA cell cohorts, RNA activity of the Positive regulation of isotype switching pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP27P1-BPTFP1-KPNA2P3, SERPINA5, and HDAC9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP27P1-BPTFP1-KPNA2P3 grouped by Positive regulation of isotype switching-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ARHGAP27P1-BPTFP1-KPNA2P3 →	+0.562	+0.248	.001	.004	2	5
LUNG_NSCLC_LUAD	SERPINA5 →	+0.217	+0.206	.003	.004	3	4
OVARY	HDAC9 →	-0.146	-0.291	.002	.002	3	3
LUNG_SCLC	ZGPAT →	+0.131	+0.281	.001	.006	3	3
SOFT_TISSUE	TNIK →	+0.195	+0.239	.005	.001	2	4
UPPER_AERODIGESTIVE_TRACT	CCR8 →	+0.198	+0.234	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP27P1-BPTFP1-KPNA2P3 by Positive regulation of isotype switching activity — OESOPHAGUS

Explore this box plot interactively →