Transcription initiation-coupled chromatin remodeling

Across TCGA patient cohorts, RNA activity of the Transcription initiation-coupled chromatin remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAN2A1, ZMYM3, and VCAN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription initiation-coupled chromatin remodeling activity versus MAN2A1 in GBM (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAN2A1 →	-0.283	-0.038	.005	<.001	3	6
UCEC	ZMYM3 →	+0.343	+0.079	<.001	<.001	3	5
GBM	VCAN →	+0.814	+0.043	<.001	<.001	3	5
UCEC	BCL11A_S432 →	+0.748	+0.079	.005	<.001	3	4
HNSC	CMTR1 →	+0.221	+0.060	.001	.004	3	4
LSCC	TP53 →	+1.179	+0.032	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045815 vs MAN2A1 — GBM

Explore this scatter interactively →