Negative regulation of endocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAB1, ANKRD44, and LSP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endocytosis activity versus STAB1 in GBM (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STAB1 →	+0.574	+0.048	<.001	<.001	3	10
LSCC	ANKRD44 →	+0.474	+0.069	<.001	<.001	3	10
GBM	LSP1 →	+0.615	+0.039	<.001	<.001	3	10
LSCC	RCSD1 →	+0.578	+0.049	<.001	<.001	3	9
CCRCC	ARRB2 →	+0.265	+0.040	<.001	<.001	3	9
COAD	RIN3 →	+0.586	+0.035	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045806 vs STAB1 — GBM

Explore this scatter interactively →