Positive regulation of cell size

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell size pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM1A, HSP90AA1, and DERL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM1A grouped by Positive regulation of cell size-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KDM1A →	-0.437	-1.280	.003	.009	3	8
SKIN	HSP90AA1 →	-0.273	-0.307	<.001	.002	3	8
BONE	DERL1 →	+0.165	+0.388	.005	.003	3	4
UPPER_AERODIGESTIVE_TRACT	NAA20 →	+0.250	+1.199	.002	.005	3	4
BREAST	TMC1 →	+0.152	+0.345	.001	.005	3	4
LUNG_SCLC	MAP3K7 →	-0.406	-1.035	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM1A by Positive regulation of cell size activity — KIDNEY

Explore this box plot interactively →