Positive regulation of blood pressure

Across TCGA patient cohorts, RNA activity of the Positive regulation of blood pressure pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COPA, MCM4, and MCM6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood pressure activity versus COPA in BRCA (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COPA →	+0.191	+0.050	<.001	.001	3	6
UCEC	MCM4 →	-0.333	-0.064	.004	.003	3	5
UCEC	MCM6 →	-0.472	-0.095	.004	.001	3	5
UCEC	MCM7 →	-0.365	-0.064	.001	.004	3	5
GBM	TNKS1BP1_S228 →	+0.490	+0.057	.003	<.001	3	5
LSCC	SEC31A →	+0.218	+0.054	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045777 vs COPA — BRCA

Explore this scatter interactively →