Positive regulation of adenylate cyclase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of adenylate cyclase activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BAZ1B, UNG_S23, and CUL4B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of adenylate cyclase activity activity versus BAZ1B in BRCA (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BAZ1B →	-0.320	-0.030	.001	<.001	3	5
LSCC	UNG_S23 →	-0.745	-0.042	<.001	<.001	3	5
HNSC	CUL4B →	-0.196	-0.053	.004	.001	3	5
LSCC	FLNB →	+0.401	+0.052	.002	<.001	3	5
LSCC	PHIP_S911 →	-0.519	-0.047	.001	<.001	3	5
UCEC	ARID2 →	-0.276	-0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045762 vs BAZ1B — BRCA

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