Regulation of adenylate cyclase activity

Across TCGA patient cohorts, RNA activity of the Regulation of adenylate cyclase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBR5, GTF2I, and MSH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adenylate cyclase activity activity versus UBR5 in LSCC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBR5 →	-0.244	-0.049	<.001	<.001	3	6
HNSC	GTF2I →	-0.385	-0.051	<.001	.005	3	6
HNSC	MSH2 →	-0.519	-0.052	<.001	<.001	3	6
UCEC	PITPNA →	+0.235	+0.044	.002	<.001	3	6
BRCA	DDX18 →	-0.510	-0.038	<.001	<.001	3	6
BRCA	INTS13 →	-0.272	-0.034	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045761 vs UBR5 — LSCC

Explore this scatter interactively →