Regulation of adenylate cyclase activity

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of adenylate cyclase activity pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 45 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Regulation of adenylate cyclase activity pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and BRCA, show the opposite pattern, with higher activity associated with better survival.

UVM, MESO, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.952	0.327	<.001	110	view →
MESO	OS	Median	II,III,IV	0.273	0.503	.001	77	view →
BRCA	OS	Tertile	II,III,IV	0.955	0.883	.002	47	view →
LGG	DFS	Median	All	0.893	0.791	<.001	40	view →
READ	OS	Quartile	All	0.581	1.000	.001	38	view →
SKCM	DFS	Median	II,III,IV	0.164	0.346	<.001	38	view →
HNSC	OS	Median	All	0.693	0.816	.002	37	view →
LUAD	OS	Quartile	All	0.680	0.399	.001	31	view →
KIRC	DFS	Quartile	IV	0.162	0.497	.010	25	view →
PCPG	OS	Quartile	All	0.757	1.000	.004	19	view →
ESCA	OS	Tertile	All	1.000	0.470	.006	19	view →
TGCT	DFS	Median	All	0.911	0.759	.016	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0045761–UVM (OS)

Open the UVM breakdown →