Regulation of adenylate cyclase activity

Across TCGA cell cohorts, RNA activity of the Regulation of adenylate cyclase activity pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IREB2, MBTD1, and CGN, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adenylate cyclase activity activity versus IREB2 in LIVER (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IREB2 →	-0.968	-0.200	.001	.003	3	12
BONE	MBTD1 →	-1.169	-0.124	<.001	<.001	3	12
LIVER	CGN →	-2.885	-0.208	<.001	<.001	3	11
LIVER	RMND5A →	-0.970	-0.180	<.001	<.001	3	10
BONE	ZNF124 →	-1.199	-0.112	<.001	<.001	3	10
LUNG_SCLC	POU2F1 →	-0.791	-0.127	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045761 vs IREB2 — LIVER

Explore this scatter interactively →