Negative regulation of action potential

Across TCGA patient cohorts, RNA activity of the Negative regulation of action potential pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIN1, CNR1, and DOCK8, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of action potential activity versus BIN1 in UCS (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	BIN1 →	+2.005	+0.133	<.001	<.001	3	28
UCS	CNR1 →	-1.567	-0.143	.005	<.001	2	26
SCLC	DOCK8 →	-1.912	-1.012	<.001	<.001	3	24
UCS	TCP11L2 →	-0.755	-0.110	<.001	<.001	3	23
UVM	RBL2 →	-1.291	-0.095	<.001	<.001	2	23
KICH	PLCG2 →	-1.355	-0.095	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045759 vs BIN1 — UCS

Explore this scatter interactively →