Negative regulation of action potential

Across TCGA patient cohorts, RNA activity of the Negative regulation of action potential pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BIN1, METTL7B, and RASAL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of action potential activity versus BIN1 in HNSC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BIN1 →	+0.718	+0.110	<.001	<.001	3	6
HNSC	METTL7B →	+0.553	+0.125	.001	<.001	3	6
COAD	RASAL3 →	-0.234	-0.061	.002	<.001	3	6
UCEC	SHMT2 →	+0.424	+0.091	<.001	.001	3	5
COAD	VAPB →	+0.279	+0.058	<.001	<.001	3	5
LUAD	CDH1 →	+0.418	+0.115	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045759 vs BIN1 — HNSC

Explore this scatter interactively →