Negative regulation of action potential

Across TCGA patient cohorts, RNA activity of the Negative regulation of action potential pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSM5, BIN1, and GIMAP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of action potential activity versus ACSM5 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACSM5 →	+0.704	+0.602	<.001	.004	3	4
GBM	BIN1 →	+0.892	+0.699	<.001	<.001	3	4
HNSC	GIMAP6 →	+0.788	+0.176	<.001	.002	3	4
HNSC	PLPP7 →	+0.671	+0.213	<.001	<.001	3	4
HNSC	RCAN2 →	+0.631	+0.162	<.001	<.001	3	4
UCEC	GIMAP7 →	+0.615	+0.126	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045759 vs ACSM5 — BRCA

Explore this scatter interactively →