Positive regulation of Notch signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of Notch signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUSC1, YAP1, and FOXQ1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Notch signaling pathway activity versus TUSC1 in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TUSC1 →	+0.696	+0.183	.003	.002	3	4
CCRCC	YAP1 →	+0.278	+0.224	.008	.003	3	3
OV	FOXQ1 →	+1.597	+0.517	<.001	.002	3	3
PDAC	RASGRF2 →	+0.393	+0.196	.004	.006	3	3
BRCA	GPR68 →	+0.878	+0.746	<.001	.005	2	4
BRCA	SYN2 →	+0.795	+0.696	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045747 vs TUSC1 — LSCC

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