Negative regulation of G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RANGRF, MVP, and CASP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RANGRF grouped by Negative regulation of G protein-coupled receptor signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RANGRF →	+0.735	+1.015	.007	<.001	3	4
BLOOD_Leukemia	MVP →	-1.213	-0.849	.005	.009	3	4
CNS	CASP2 →	+0.674	+0.559	.005	.009	3	3
CNS	HOXD10 →	+2.254	+0.557	.001	.007	3	3
CNS	IHH →	+0.054	+0.517	<.001	<.001	3	3
BLOOD_Myeloma	ZRSR2 →	+0.642	+1.611	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RANGRF by Negative regulation of G protein-coupled receptor signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →