Negative regulation of G protein-coupled receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of G protein-coupled receptor signaling pathway pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 54 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Negative regulation of G protein-coupled receptor signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and COAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, THYM, and GBM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.439	0.790	<.001	141	view →
THYM	DFS	Median	II,III,IV	0.399	0.873	.007	27	view →
GBM	OS	Quartile	All	0.304	0.488	.002	24	view →
UCS	OS	Median	IV	0.817	0.302	.002	24	view →
THCA	OS	Median	II,III,IV	0.910	0.977	.011	22	view →
ESCA	OS	Median	II,III,IV	0.588	0.787	.003	21	view →
COAD	DFS	Median	All	0.835	0.746	.007	19	view →
PAAD	DFS	Median	II,III,IV	0.582	0.355	.006	18	view →
LUAD	DFS	Tertile	IV	0.385	0.752	.025	18	view →
ACC	OS	Tertile	II,III,IV	0.572	0.919	.003	16	view →
PRAD	DFS	Median	All	0.923	0.862	.025	6	view →
CESC	DFS	Median	IV	0.652	0.324	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0045744–KIRP (OS)

Open the KIRP breakdown →