Negative regulation of G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR43, MRM3, and PDCD2L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of G protein-coupled receptor signaling pathway activity versus WDR43 in LUNG_SCLC (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	WDR43 →	-0.666	-0.488	.002	.009	3	5
KIDNEY	MRM3 →	-0.932	-0.358	.004	.001	3	5
URINARY_TRACT	PDCD2L →	-1.099	-0.353	.007	.001	3	5
PANCREAS	TNFRSF12A →	+1.111	+0.445	.002	.007	3	5
SKIN	NRM →	+0.755	+0.296	<.001	.001	3	5
LIVER	TLCD1 →	-1.420	-0.537	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045744 vs WDR43 — LUNG_SCLC

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