Positive regulation of DNA replication

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AOC3, WBP1L, and TTK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA replication activity versus AOC3 in LSCC (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AOC3 →	-0.649	-0.723	<.001	<.001	3	5
GBM	WBP1L →	-0.347	-0.795	<.001	<.001	3	5
BRCA	TTK →	+1.151	+0.696	<.001	<.001	3	5
GBM	CDCA8 →	+0.901	+0.685	<.001	<.001	3	5
GBM	CKAP2L →	+1.003	+0.838	<.001	<.001	3	5
GBM	STIL →	+1.068	+1.180	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045740 vs AOC3 — LSCC

Explore this scatter interactively →