Positive regulation of DNA replication

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of DNA replication pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 38 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Positive regulation of DNA replication pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRC, ACC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.486	0.712	<.001	166	view →
ACC	DFS	Median	All	0.204	0.681	<.001	141	view →
MESO	DFS	Tertile	All	0.270	0.498	<.001	102	view →
LIHC	DFS	Median	All	0.443	0.612	<.001	88	view →
KICH	OS	Tertile	II,III,IV	0.307	1.000	<.001	76	view →
HNSC	OS	Tertile	IV	0.562	0.287	.001	66	view →
UCS	OS	Median	II,III,IV	0.601	0.220	.001	64	view →
READ	OS	Quartile	All	0.881	0.487	<.001	63	view →
KIRP	OS	Tertile	All	0.518	0.819	<.001	44	view →
LUAD	OS	Median	All	0.291	0.434	<.001	38	view →
LGG	OS	Tertile	All	0.721	0.850	<.001	28	view →
CESC	OS	Median	II,III,IV	0.635	0.300	.014	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0045740–KIRC (OS)

Open the KIRC breakdown →