Positive regulation of DNA replication

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRIP1, CLMN, and DLL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA replication activity versus GRIP1 in OESOPHAGUS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GRIP1 →	+1.760	+0.190	.004	.002	3	4
BLOOD_Myeloma	CLMN →	+1.860	+0.126	.002	<.001	3	4
BLOOD_Myeloma	DLL1 →	+0.048	+0.140	.003	.009	3	4
OVARY	UCHL5 →	+0.924	+0.214	.005	.003	3	4
SKIN	MTFR2 →	+0.606	+0.168	.003	<.001	3	4
OVARY	CDT1 →	+1.187	+0.188	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045740 vs GRIP1 — OESOPHAGUS

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