Positive regulation of DNA repair

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF629, SCAMP3, and SERGEF, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA repair activity versus ZNF629 in BRCA (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF629 →	+1.626	+0.353	.006	.003	3	2
BRCA	SCAMP3 →	+1.586	+0.353	.003	.003	3	2
BRCA	SERGEF →	+1.309	+0.248	.003	.007	3	2
BRCA	USP21 →	+1.626	+0.353	<.001	.003	3	2
BRCA	ZNF687 →	+1.703	+0.353	<.001	.003	3	2
BRCA	ANKMY1 →	+1.106	+0.269	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045739 vs ZNF629 — BRCA

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