Negative regulation of DNA repair

Across TCGA patient cohorts, RNA activity of the Negative regulation of DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXM1, TICRR, and PRC1-AS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA repair activity versus FOXM1 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOXM1 →	+0.918	+0.806	<.001	<.001	3	7
BRCA	TICRR →	+0.679	+0.752	<.001	<.001	3	7
UCEC	PRC1-AS1 →	+0.554	+0.251	<.001	.005	3	6
BRCA	TPX2 →	+0.950	+0.909	.001	<.001	3	6
GBM	BUB1B →	+0.908	+0.804	<.001	<.001	3	6
PDAC	ARHGAP11B →	+0.264	+0.921	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045738 vs FOXM1 — BRCA

Explore this scatter interactively →