Negative regulation of DNA repair

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA repair pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM157A, WBP11, and ARL2BP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM157A grouped by Negative regulation of DNA repair-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FAM157A →	+0.159	+0.268	<.001	<.001	3	4
PANCREAS	WBP11 →	-0.289	-0.188	.002	.003	3	4
UPPER_AERODIGESTIVE_TRACT	ARL2BP →	+0.379	+0.329	.003	.001	3	4
OESOPHAGUS	SNRPG →	+0.312	+0.346	.002	.001	3	4
OESOPHAGUS	OSGEP →	-0.272	-0.279	<.001	<.001	3	4
OVARY	H4C9 →	+0.266	+0.463	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM157A by Negative regulation of DNA repair activity — KIDNEY

Explore this box plot interactively →