Negative regulation of DNA repair

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHMP5, KSR1, and PDE8A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHMP5 grouped by Negative regulation of DNA repair-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CHMP5 →	+0.579	+0.303	.002	.002	3	4
KIDNEY	KSR1 →	+1.651	+0.254	.001	.001	3	4
OESOPHAGUS	PDE8A →	+1.009	+0.193	.006	.005	3	3
BLOOD_Myeloma	ANKRD12 →	+2.159	+0.241	.005	.005	3	3
BLOOD_Myeloma	KDM4B →	+1.046	+0.201	.006	.008	2	4
BLOOD_Myeloma	WBP2 →	+0.451	+0.274	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHMP5 by Negative regulation of DNA repair activity — BLOOD_Leukemia

Explore this box plot interactively →