Negative regulation of DNA repair

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA repair pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED11, SRRM5, and PHF23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA repair activity versus MED11 in OVARY (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MED11 →	+0.628	+0.166	.003	.004	3	5
LUNG_SCLC	SRRM5 →	-0.578	-0.137	.008	.003	2	5
OVARY	PHF23 →	+0.830	+0.202	.001	.005	2	5
BLOOD_Myeloma	MROH6 →	-1.498	-0.284	<.001	<.001	3	4
BLOOD_Leukemia	GNMT →	-0.493	-0.109	.004	.002	3	4
CNS	CLDN23 →	-0.531	-0.166	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045738 vs MED11 — OVARY

Explore this scatter interactively →