Positive regulation of protein catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF783, OSTM1, and MIGA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein catabolic process activity versus ZNF783 in BLOOD_Myeloma (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZNF783 →	-0.649	-0.193	.009	.006	3	5
BLOOD_Leukemia	OSTM1 →	+0.634	+0.117	.004	<.001	3	4
CNS	MIGA2 →	-0.348	-0.135	.004	.002	3	4
BONE	AMN1 →	+1.480	+0.135	.004	.001	3	4
LUNG_SCLC	RARS2 →	+0.563	+0.129	<.001	<.001	3	4
LIVER	RETREG1 →	-1.339	-0.153	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045732 vs ZNF783 — BLOOD_Myeloma

Explore this scatter interactively →