Positive regulation of translation

Across TCGA patient cohorts, RNA activity of the Positive regulation of translation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNO, LACC1, and COX17P1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of translation activity versus CCNO in BRCA (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCNO →	-3.829	-0.226	.008	.006	3	2
BRCA	LACC1 →	-1.186	-0.220	.005	.002	3	2
BRCA	COX17P1 →	+1.623	+0.254	.009	<.001	3	2
OV	EIF4A1P6 →	+0.669	+0.161	.002	.003	3	2
COAD	MTND4LP30 →	+1.189	+0.157	.004	.008	3	2
COAD	MTCO1P53 →	+1.202	+0.224	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045727 vs CCNO — BRCA

Explore this scatter interactively →