Positive regulation of gluconeogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of gluconeogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAG2, CRY1, and DNAJC9, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gluconeogenesis activity versus PRKAG2 in SKIN (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRKAG2 →	+1.311	+0.082	<.001	<.001	3	13
KIDNEY	CRY1 →	+1.314	+0.121	.002	<.001	3	13
LIVER	DNAJC9 →	+1.051	+0.106	.001	.002	3	13
LIVER	OSBPL8 →	+0.843	+0.112	<.001	<.001	3	13
BLOOD_Lymphoma	SIRT1 →	+0.982	+0.107	<.001	<.001	3	12
LIVER	DDX50 →	+0.787	+0.107	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045722 vs PRKAG2 — SKIN

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