Negative regulation of fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of fatty acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1247, CBX2, and CHTF18_S871, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid biosynthetic process activity versus TOP2A_S1247 in HNSC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOP2A_S1247 →	+0.713	+0.063	<.001	.001	3	5
PDAC	CBX2 →	+1.122	+0.078	.005	.001	3	5
HNSC	CHTF18_S871 →	+0.471	+0.081	.001	<.001	3	5
GBM	NCL_S67 →	+0.662	+0.067	<.001	<.001	3	5
CCRCC	PPM1F →	-0.252	-0.039	<.001	.002	3	5
UCEC	EPB41L2 →	-0.304	-0.055	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045717 vs TOP2A_S1247 — HNSC

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