Regulation of epidermis development

Across TCGA patient cohorts, RNA activity of the Regulation of epidermis development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYFIP2, KRT17, and KRT80, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epidermis development activity versus CYFIP2 in LSCC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CYFIP2 →	-0.403	-0.039	.003	<.001	3	6
UCEC	KRT17 →	+1.190	+0.057	<.001	<.001	3	6
LSCC	KRT80 →	+0.724	+0.039	.009	<.001	3	6
HNSC	CD2 →	-0.457	-0.045	<.001	<.001	3	5
PDAC	TRIM29 →	+1.070	+0.033	<.001	<.001	3	5
PDAC	YWHAQ →	+0.233	+0.034	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045682 vs CYFIP2 — LSCC

Explore this scatter interactively →