Regulation of epidermis development

Across TCGA patient cohorts, RNA activity of the Regulation of epidermis development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PODN, TMEM132C, and RBMS3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epidermis development activity versus PODN in BRCA (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PODN →	-1.209	-0.730	.002	.005	3	6
OV	TMEM132C →	-1.294	-0.746	.006	.001	3	6
BRCA	RBMS3 →	-0.825	-0.996	<.001	<.001	3	6
OV	PLPPR4 →	-0.690	-0.668	.003	.002	3	5
GBM	MAP1A →	-0.725	-1.109	<.001	<.001	3	5
HNSC	PDE4DIP →	-0.494	-0.486	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045682 vs PODN — BRCA

Explore this scatter interactively →