Regulation of epidermis development

Across TCGA cell cohorts, RNA activity of the Regulation of epidermis development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUOX1, RBM4, and HOXB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epidermis development activity versus DUOX1 in PANCREAS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DUOX1 →	+1.207	+0.314	.001	.001	3	5
BLOOD_Lymphoma	RBM4 →	+0.525	+0.117	.003	.008	3	5
CNS	HOXB2 →	-4.173	-0.289	<.001	.001	3	5
SOFT_TISSUE	TXNDC12 →	-0.928	-0.285	.005	.005	3	4
OVARY	TMEM53 →	-0.762	-0.190	.002	.002	3	4
LUNG_NSCLC_LUAD	PFDN2 →	-0.696	-0.161	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045682 vs DUOX1 — PANCREAS

Explore this scatter interactively →