Negative regulation of osteoclast differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCAT, MIR223HG, and GAL3ST2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of osteoclast differentiation activity versus GCAT in HNSC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GCAT →	-0.962	-0.327	<.001	.008	3	4
GBM	MIR223HG →	+0.609	+0.242	.001	.004	3	4
UCEC	GAL3ST2 →	-0.614	-0.454	.007	.002	3	4
UCEC	LINC01063 →	-0.632	-0.403	<.001	.001	3	4
HNSC	TIMM44 →	-0.591	-0.430	.004	.003	3	4
HNSC	GCDH →	-0.440	-0.346	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045671 vs GCAT — HNSC

Explore this scatter interactively →