Regulation of osteoblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS51, RPL27A, and COMP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoblast differentiation activity versus VPS51 in URINARY_TRACT (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	VPS51 →	+0.716	+0.262	<.001	<.001	3	4
STOMACH	RPL27A →	+0.956	+0.682	.001	.006	3	4
SOFT_TISSUE	COMP →	-0.399	-0.242	.005	.002	3	3
SOFT_TISSUE	RPL27 →	+0.576	+0.278	<.001	<.001	3	3
LIVER	LYRM4 →	+0.637	+0.254	.001	.001	3	3
SOFT_TISSUE	SERHL2 →	-0.855	-0.270	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045667 vs VPS51 — URINARY_TRACT

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