Negative regulation of neuron differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, CSF1R, and RTP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron differentiation activity versus HLA-B in PANCREAS (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HLA-B →	+3.444	+0.326	<.001	<.001	3	6
BLOOD_Lymphoma	CSF1R →	+2.362	+0.265	.002	.002	3	6
CNS	RTP4 →	+1.887	+0.257	.005	.002	3	5
CNS	ADPRH →	+1.376	+0.214	.003	.005	3	5
BLOOD_Lymphoma	TAP1 →	+2.085	+0.327	<.001	<.001	3	5
BLOOD_Leukemia	ITGAE →	-1.134	-0.154	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045665 vs HLA-B — PANCREAS

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