Regulation of neuron differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, RPLP1, and NDUFS6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron differentiation activity versus MAP1B in BRCA (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAP1B →	+1.093	+1.444	.001	<.001	3	3
COAD	RPLP1 →	+0.293	+0.289	.001	<.001	3	2
COAD	NDUFS6 →	+0.362	+0.287	.003	.002	3	2
COAD	OR1A1 →	+0.008	+0.273	<.001	.008	3	2
COAD	TRDN →	+0.023	+0.314	.004	.006	3	2
COAD	HYKK →	+0.190	+0.264	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045664 vs MAP1B — BRCA

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