Negative regulation of myoblast differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMTK3, EDNRA, and MEAF6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myoblast differentiation activity versus LMTK3 in LUNG_SCLC (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LMTK3 →	-2.425	-0.226	.007	.005	2	4
LUNG_NSCLC_LUAD	EDNRA →	-1.840	-0.350	.001	.007	3	2
LUNG_NSCLC_LUAD	MEAF6 →	+0.735	+0.305	.005	.006	3	2
LUNG_NSCLC_LUAD	NDST2 →	+0.724	+0.327	<.001	.002	3	2
LUNG_NSCLC_LUAD	CSGALNACT2 →	+0.923	+0.312	.006	.004	3	2
LUNG_NSCLC_LUAD	CD164L2 →	-0.562	-0.333	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045662 vs LMTK3 — LUNG_SCLC

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