Positive regulation of monocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of monocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOB2, LMAN2L, and VPS25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MOB2 grouped by Positive regulation of monocyte differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MOB2 →	+0.865	+1.136	.003	.006	3	4
LARGE_INTESTINE	LMAN2L →	+0.555	+0.729	.003	.004	3	4
OESOPHAGUS	VPS25 →	-0.844	-1.604	.001	.004	3	3
OESOPHAGUS	IGF2 →	+2.172	+1.320	.003	.003	3	3
OESOPHAGUS	KRT8 →	-2.088	-1.105	.005	.003	3	3
OESOPHAGUS	MACC1 →	-2.088	-1.315	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MOB2 by Positive regulation of monocyte differentiation activity — STOMACH

Explore this box plot interactively →