Negative regulation of monocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of monocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIN2, ADAMTS7P4, and FZR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monocyte differentiation activity versus BIN2 in GBM (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BIN2 →	+0.759	+0.819	<.001	<.001	3	6
LSCC	ADAMTS7P4 →	+0.206	+0.567	<.001	<.001	3	6
BRCA	FZR1 →	-0.656	-0.694	<.001	<.001	3	6
HNSC	CARD8-AS1 →	+0.536	+0.533	.001	<.001	3	6
HNSC	TRGC1 →	+0.874	+0.545	.001	.002	3	6
LUAD	GMEB2 →	-0.379	-0.535	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045656 vs BIN2 — GBM

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